When we look at our basic codes, we see that the main information that makes us up is hidden in the sequence of nucleotides that we define...
When we look at our basic codes, we see that the main information that makes us up is hidden in the sequence of nucleotides that we define as A, T, G, S and participate in the structure of DNA. However, at the point we have reached today, we can say that the learning we carry out while organizing our lives is reflected in our behavior through our epigenetic mechanisms. Through these epigenetic mechanisms, the change in our behavior is transmitted to future generations through epigenetic inheritance. In fact, our lifestyles may be regulated through epigenetics. In addition, our living habits are also evolving with epigenetics. In other words, whatever has been encoded in our memory since the embryonic period can turn into our habits and later our lifestyles. Our habits are also included in our learning. In this way, what we gain and what we lose becomes our life. Our diets, Our parental nutrition, the stress we experience, the medications we use, and all our learning form our epigenetic identity. In fact, what we code on top of our basic codes is often related to epigenetics. The psychology involved here offers a perspective on how our spiritual development changes our biological mechanisms. Spiritual development can give ideas on how to improve biological mechanisms that are damaged by our lifestyle. Because if the learning we have acquired since the embryonic period and the negative interactions in the memory can be transformed through psychology and personal development, it may be possible to create epigenetic solutions.
In other words, the stress, trauma, If it can transform factors such as negative nutritional conditions through psychology and contribute to personal development, epigenetic mechanisms will be positively affected and a contribution can be made to the next generation. Although research on the subject has increased, it seems clear that there are many issues that need to be studied. In addition, all other individuals will benefit from the synergy that begins with the change in the lifestyle of only one individual. And this situation is affected not only by us but also by our relationship with other living things. In order to make our shared life with living things more creative, illuminating our epigenetic mechanisms can contribute to the transformation of traumas in our souls. Thus, it may be possible to take steps for the expected universal healing. In addition, all other individuals will benefit from the synergy that begins with the change in the lifestyle of just one individual. And this situation is affected not only by us but also by our relationship with other living things. In order to make our shared life with living things more creative, illuminating our epigenetic mechanisms can contribute to the transformation of traumas in our souls. Thus, it may be possible to take steps for the expected universal healing. In addition, all other individuals will benefit from the synergy that begins with the change in the lifestyle of just one individual. And this situation is affected not only by us but also by our relationship with other living things. In order to make our shared life with living things more creative, illuminating our epigenetic mechanisms can contribute to the transformation of traumas in our souls. Thus, it may be possible to take steps for the expected universal healing.
The Effect of Lifestyles on Epigenetics
The term lifestyle is commonly used to describe typical lifestyle or lifestyle. The characteristic of an individual or group includes different factors such as this concept. Such as diet, behavior, stress, physical activity, work habits, smoking and alcohol consumption[1]. Genomic DNA in eukaryotes forms a highly organized structure called chromatin[1]. Genomic function is determined by a combination of DNA sequence and molecular mechanisms that control access to genetic information[3]. Epigenetic regulation of genes involves DNA methylation and modifications of histone tails, such as acetylation and methylation, that lead to a particular phenotype without a change in nucleotide sequence. Both genetic and environmental factors play important roles in the development of lifestyle diseases[2]. Increasing environmental and lifestyle factors can affect epigenetic mechanisms such as DNA. For example, Methylation, histone modifications and microRNA expression. Changes in epigenetic marks are also associated with various human diseases such as cancer, cardiovascular, respiratory and neurodegenerative [1].
foods
Folic acid and vitamin B12 play an important role in DNA metabolism, and the synthesis of methionine and S-adenosylmethionine (SAM) is essential for the maintenance of methylation patterns in common methyl donor DNA. The SAM:SAH ratio is the main determinant of methylation capacity because SAM is converted to SAH (S-adenosylhomocysteine) by methionine adenosyltransferase. Considering that methionine regenerates homocysteine methylation via folate- and B12-dependent reactions, a folate-deficient diet may interfere with this system. The SAM/SAH ratio is associated with DNA methylation patterns. For example, a study in rats examined maternal folate DNA methylation in the placenta. A significant positive correlation was found between placental DNA methylation, hepatic and plasma folate levels, and hepatic SAM/SAH ratio. Low folate intakes have also been associated with colorectal cancer risk. Polyphenols are a large family of natural compounds widely distributed in plant foods that have been shown to alter the activity of DNA methyltransferases, histone acetylases (Hats) and histone deacetylases (HDACs). In particular, studies on cancer cells have shown that polyphenols can reverse malignant transformations in some epigenetic models in in-vitro models[1].
Obesity and Physical Activity
Overweight, obesity and a sedentary lifestyle are common risk factors for various diseases, including cancer and cardiovascular disease. Because body weight is regulated by genes that control energy homeostasis. Dietary macronutrients that affect DNA methylation may contribute to the development of obesity through epigenetic mechanisms[1].
Cigarettes and alcohol
Cigarette smoke contains a complex mixture of organic and inorganic chemicals, many of which have carcinogenic, pro-inflammatory and pro-eratogenic properties. The individual effects of these components have been examined by different epigenetic studies, but the results are still poorly known. Unlike polycyclic aromatic hydrocarbons (PAHs) and other carcinogenic molecules, ethyl alcohol found in tobacco smoke and tar is not mutagenic per se, but rather acts primarily as a cocarcinogen. A study on diet and cancer linked folate and alcohol use with methylation changes in tumor suppressor and DNA repair genes[1].
Indeed, when looked at, it can be seen that each epigenetic change is like the fingerprint of each individual. Because each individual's lifestyle, habits and experiences are different. Therefore, people's epigenetic memory also changes according to their lifestyle. These differences may manifest themselves epigenetically in future studies. It seems that both biological and psychological studies will be the key to vital transformations in the individual's journey to becoming himself.
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